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Article

Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.

Pharmacogenetics and genomics - 1 Sept 2011

Negi Sapna, Kumar Ashok, Thelma B K, Juyal Ramesh C

Abstract excerpt

Aberrations in ubiquitin pathway have been implicated in many diseases and drug response. In a previous study on rheumatoid arthritis (RA) in Japanese population, significant association of Cullin1 gene (CUL1), an ubiquitin E3 ligase, was observed. CUL1 also mediates degradation of IκBα and p27, levels of which has been associated with RA etiology and drug response, respectively. We carried out a replication...

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Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21738080
DOI: 10.1097/FPC.0b013e3283492af7

Genes

CUL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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