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Article

RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2014

Kung Tabitha N, Dennis Jessica, Ma Yiqing, Xie Gang, Bykerk Vivian, Pope Janet, Thorne Carter, Keystone Edward, Siminovitch Katherine A, Gagnon France

Abstract excerpt

OBJECTIVE: Associations have been reported between candidate genes and the response to methotrexate (MTX) in rheumatoid arthritis (RA) patients, but most of the studies have been small and have yielded conflicting results. This study was undertaken to provide a systematic review of all genetic variant associations with MTX efficacy and toxicity, and to conduct a meta-analysis evaluating the most commonly studied...

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Share to Antirheumatic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Reduced Folate Carrier Protein

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Source

Identifiers

PMID: 24782176
DOI: 10.1002/art.38331

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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