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Article

Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors.

Current opinion in pharmacology - 1 Oct 2020

Zhang Kai Xi, Ip Chi Kio, Chung Sookja Kim, Lei Kei Kei, Zhang Yao Qian, Liu Liang, Wong Vincent Kam Wai

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease that is associated with chronic inflammation in joints, which contribute to synovial membrane hyperplasia and cartilage damage. Conventional disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX) and leflunomide (LEF), are the common RA therapy to reduce inflammation and disease progression. Recently, drug-resistance in RA with conventional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32942096
DOI: 10.1016/j.coph.2020.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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