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Article

Uromodulin gene variant is associated with type 2 diabetic nephropathy.

Journal of hypertension - 1 Sept 2011

Ahluwalia Tarunveer S, Lindholm Eero, Groop Leif, Melander Olle

Abstract excerpt

AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney disease (CKD). In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21738052
DOI: 10.1097/HJH.0b013e328349de25

Genes

UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Uromodulin gene variant is associated with type 2 diabetic nephropathy.PMID 21738052Read ↗

Uromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes.Semantic proximity Read ↗

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.Semantic proximity Read ↗

UMOD Polymorphisms Associated With Kidney Function, Serum Uromodulin and Risk of Mortality Among Patients With Chronic Kidney Disease, Results From the C-STRIDE studySemantic proximity Read ↗

UMOD and the architecture of kidney diseaseSemantic proximity Read ↗

Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.Semantic proximity Read ↗

Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.Semantic proximity Read ↗

UMOD Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study.Semantic proximity Read ↗

Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort.Semantic proximity Read ↗

The value of uromodulin as a new serum marker to predict decline in renal function.Semantic proximity Read ↗

Uromodulin levels associate with a common UMOD variant and risk for incident CKD.Semantic proximity Read ↗

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.Semantic proximity Read ↗

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.Semantic proximity Read ↗

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