Article
Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.
PLoS genetics - 29 Jul 2010
Gudbjartsson Daniel F, Holm Hilma, Indridason Olafur S, Thorleifsson Gudmar, Edvardsson Vidar, Sulem Patrick, de Vegt Femmie, d'Ancona Frank C H, den Heijer Martin, Wetzels Jack F M, Franzson Leifur, Rafnar Thorunn, Kristjansson Kristleifur, Bjornsdottir Unnur S, Eyjolfsson Gudmundur I, Kiemeney Lambertus A, Kong Augustine, Palsson Runolfur, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Chronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality. To search for sequence variants that associate with CKD, we conducted a genome-wide association study (GWAS) that included a total of 3,203 Icelandic cases and 38,782 controls. We observed an association between CKD and a variant with 80% population frequency, rs4293393-T, positioned next...
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