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Article

Uromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes.

The Indian journal of medical research - 1 Nov 2017

Kumar Vinod, Yadav Ashok Kumar, Kumar Vivek, Bhansali Anil, Jha Vivekanand

Abstract excerpt

Background & objectives: Uromodulin, a UMOD gene encoded glycoprotein is synthesized exclusively in renal tubular cells and released into urine. Mutations lead to uromodulin misfolding and retention in the kidney, where it might stimulate cells of immune system to cause inflammation and progression of kidney disease. Genome-wide association studies (GWAS) have identified UMOD locus to be associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29578190
DOI: 10.4103/ijmr.IJMR_919_16
PMCID: PMC5890591

Genes

UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Uromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes.PMID 29578190Read ↗

Uromodulin gene variant is associated with type 2 diabetic nephropathy.Semantic proximity Read ↗

Study of Uromodulin Gene Polymorphism in Egyptian Patients with End-Stage Renal Disease.Semantic proximity Read ↗

UMOD Polymorphisms Associated With Kidney Function, Serum Uromodulin and Risk of Mortality Among Patients With Chronic Kidney Disease, Results From the C-STRIDE studySemantic proximity Read ↗

Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.Semantic proximity Read ↗

Uromodulin: from monogenic to multifactorial diseases.Semantic proximity Read ↗

UMOD and the architecture of kidney diseaseSemantic proximity Read ↗

Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.Semantic proximity Read ↗

The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease.Semantic proximity Read ↗

Uromodulin levels associate with a common UMOD variant and risk for incident CKD.Semantic proximity Read ↗

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.Semantic proximity Read ↗

UMOD Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study.Semantic proximity Read ↗

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.Semantic proximity Read ↗

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