Article
Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jul 2012
Han Jia, Chen Yuqing, Liu Ying, Liang Yu, Wang Xingyu, Liu Lisheng, Wang Fang, Zhang Luxia, Zhang Hong, Wang Haiyan
Abstract excerpt
Hypertension is an important risk factor for chronic kidney disease. The kidney, in turn, has an important role in the regulation of blood pressure (BP). On the basis of a genome-wide association study, single-nucleotide polymorphisms in the uromodulin (UMOD) promoter region had been considered to influence both renal sodium reabsorption and BP. In this study, we asked whether common variants across the UMOD gene...
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