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Article

Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.

Journal of the American Society of Nephrology : JASN - 1 Aug 2014

Olden Matthias, Corre Tanguy, Hayward Caroline, Toniolo Daniela, Ulivi Sheila, Gasparini Paolo, Pistis Giorgio, Hwang Shih-Jen, Bergmann Sven, Campbell Harry, Cocca Massimiliano, Gandin Ilaria, Girotto Giorgia, Glaudemans Bob, Hastie Nicholas D, Loffing Johannes, Polasek Ozren, Rampoldi Luca, Rudan Igor, Sala Cinzia, Traglia Michela, Vollenweider Peter, Vuckovic Dragana, Youhanna Sonia, Weber Julien, Wright Alan F, Kutalik Zoltán, Bochud Murielle, Fox Caroline S, Devuyst Olivier

Abstract excerpt

Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are associated with renal function, and urinary uromodulin levels may be a biomarker for kidney disease. However, the genetic factors regulating uromodulin excretion are unknown. We conducted a meta-analysis of urinary uromodulin levels to identify...

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Source

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Identifiers

PMID: 24578125
DOI: 10.1681/ASN.2013070781
PMCID: PMC4116060

Genes

UMOD
CAB39
KCNJ1
PDILT
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.PMID 24578125Read ↗

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Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.Semantic proximity Read ↗

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Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney DiseasesSemantic proximity Read ↗

UMOD Polymorphisms Associated With Kidney Function, Serum Uromodulin and Risk of Mortality Among Patients With Chronic Kidney Disease, Results From the C-STRIDE studySemantic proximity Read ↗

UMOD Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study.Semantic proximity Read ↗

Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.Semantic proximity Read ↗

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.Semantic proximity Read ↗

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