Article
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.
Nature medicine - 1 Dec 2013
Trudu Matteo, Janas Sylvie, Lanzani Chiara, Debaix Huguette, Schaeffer Céline, Ikehata Masami, Citterio Lorena, Demaretz Sylvie, Trevisani Francesco, Ristagno Giuseppe, Glaudemans Bob, Laghmani Kamel, Dell'Antonio Giacomo, Loffing Johannes, Rastaldi Maria P, Manunta Paolo, Devuyst Olivier, Rampoldi Luca
Abstract excerpt
Hypertension and chronic kidney disease (CKD) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that cause independent susceptibility to CKD and hypertension. Despite compelling genetic evidence for the association between UMOD...
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