Article
Uromodulin levels associate with a common UMOD variant and risk for incident CKD.
Journal of the American Society of Nephrology : JASN - 1 Feb 2010
Köttgen Anna, Hwang Shih-Jen, Larson Martin G, Van Eyk Jennifer E, Fu Qin, Benjamin Emelia J, Dehghan Abbas, Glazer Nicole L, Kao W H Linda, Harris Tamara B, Gudnason Vilmundur, Shlipak Michael G, Yang Qiong, Coresh Josef, Levy Daniel, Fox Caroline S
Abstract excerpt
Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR <60 ml/min per 1.73 m(2)) within the Framingham Heart...
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