Article
Urinary bladder cancer susceptibility markers. What do we know about functional mechanisms?
International journal of molecular sciences - 10 Jun 2013
Dudek Aleksandra M, Grotenhuis Anne J, Vermeulen Sita H, Kiemeney Lambertus A L M, Verhaegh Gerald W
Abstract excerpt
Genome-wide association studies (GWAS) have been successful in the identification of the several urinary bladder cancer (UBC) susceptibility loci, pointing towards novel genes involved in tumor development. Despite that, functional characterization of the identified variants remains challenging, as they mostly map to poorly understood, non-coding regions. Recently, two of the UBC risk variants (PSCA and UGT1A)...
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