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Article

Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing.

Oncogene - 1 Apr 2021

Zheng Rui, Du Mulong, Ge Yuqiu, Gao Fang, Xin Junyi, Lv Qiang, Qin Chao, Zhu Yao, Gu Chengyuan, Wang Mengyun, Zhu Qiuyuan, Guo Zheng, Ben Shuai, Chu Haiyan, Ye Dingwei, Zhang Zhengdong, Wang Meilin

Abstract excerpt

Although genome-wide association studies (GWASs) have successfully revealed many common risk variants for bladder cancer, the heritability is still largely unexplained. We hypothesized that low-frequency variants involved in bladder cancer risk could reveal the unexplained heritability. Next-generation sequencing of 113 patients and 118 controls was conducted on 81 genes/regions of known bladder cancer GWAS loci....

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Identifiers

PMID: 33658628
DOI: 10.1038/s41388-021-01672-1
PMCID: PMC8016664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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