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Article

Multiple insulin degrading enzyme variants alter in vitro reporter gene expression.

PloS one - 1 Jan 2011

Belbin Olivia, Crump Michael, Bisceglio Gina D, Carrasquillo Minerva M, Morgan Kevin, Younkin Steven G

Abstract excerpt

The insulin degrading enzyme (IDE) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar IDE mRNA, decreased plasma β-amyloid (Aβ), decreased risk for Alzheimer's disease (AD) and increased reporter gene expression, suggesting that it is a functional variant driving increased IDE expression. To identify other functional IDE variants, we have tested v685, rs11187061 (associated with...

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Identifiers

PMID: 21731745
DOI: 10.1371/journal.pone.0021429
PMCID: PMC3120874

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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