Article
Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation.
The Journal of biological chemistry - 1 Jul 2005
Kamata Tetsuji, Handa Makoto, Sato Yukiko, Ikeda Yasuo, Aiso Sadakazu
Abstract excerpt
The affinity of integrin-ligand interaction is regulated extracellularly by divalent cations and intracellularly by inside-out signaling. We report here that the extracellular, membrane-proximal alpha/beta stalk interactions not only regulate cation-induced integrin activation but also play critical roles in propagating inside-out signaling. Two closely related integrins, alphaIIbbeta3 and alphaVbeta3, share high...
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