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Article

A small cytoplasmic region adjacent to the fourth transmembrane segment of the α7 nicotinic receptor is essential for its biogenesis.

FEBS letters - 4 Aug 2011

Criado Manuel, Mulet José, Gerber Susana, Sala Salvador, Sala Francisco

Abstract excerpt

Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic α7 receptor (Glu437 to Arg447) abolished membrane expression. Different single mutants showed moderate to strong decreases in expression whereas the latter was totally abolished upon proline substitutions. We hypothesize that preservation of an α-helix formed by the fourth transmembrane segment and the adjacent...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Cattle
Cytoplasm
Membrane Proteins
Mutation
Protein Structure, Secondary
Receptors, Nicotinic
alpha7 Nicotinic Acetylcholine Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21729697
DOI: 10.1016/j.febslet.2011.06.028

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