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Article

Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors.

Journal of neurochemistry - 1 Sept 2009

Mukherjee Jayanta, Kuryatov Alexander, Moss Stephen J, Lindstrom Jon M, Anand Rene

Abstract excerpt

Mechanisms that regulate early events in the biogenesis of the alpha7 nicotinic acetylcholine receptor (alpha7 AChR) are not well understood. Data presented here show that single amino acid mutations in the cytoplasmic loop of the alpha7 AChR, between position 335 and 343, abolish or attenuate expression of mature pentameric alpha7 AChRs in both human embryonic kidney tsA201 (HEK) and neuronal SH-SY5Y cells....

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Identifiers

PMID: 19627445
DOI: 10.1111/j.1471-4159.2009.06285.x
PMCID: PMC2745714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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