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Article

A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability.

Pflugers Archiv : European journal of physiology - 1 Aug 2014

Colón-Sáez José O, Yakel Jerrel L

Abstract excerpt

The α7 neuronal nicotinic acetylcholine receptor (nAChR) displays the highest calcium permeability among the different subtypes of nAChRs expressed in the mammalian brain and can impact cellular events including neurotransmitter release, second messenger cascades, cell survival, and apoptosis. The selectivity for cations in nAChRs is thought to be achieved in part by anionic residues which are located on either...

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PMID: 24177919
DOI: 10.1007/s00424-013-1385-y
PMCID: PMC4007412

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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