Article
Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels.
The international journal of neuropsychopharmacology - 1 Jul 2012
Bromberg Anna, Lerer Elad, Udawela Madhara, Scarr Elizabeth, Dean Brian, Belmaker R H, Ebstein Richard, Agam Galila
Abstract excerpt
Emerging evidence suggests impaired one-carbon metabolism in schizophrenia. Homocysteine is one of the key components of one-carbon metabolism. Elevated plasma homocysteine levels were reported in schizophrenia. A linkage study found that nicotinamide-N-methyltransferase (NNMT), an enzyme involved in one-carbon metabolism, is a determinant of plasma homocysteine levels. In an association study the rs694539 NNMT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.