Article
Nitric oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjects.
The American journal of psychiatry - 1 Oct 2011
Hoogman Martine, Aarts Esther, Zwiers Marcel, Slaats-Willemse Dorine, Naber Marlies, Onnink Marten, Cools Roshan, Kan Cornelis, Buitelaar Jan, Franke Barbara
Abstract excerpt
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a highly heritable disorder. The NOS1 gene encoding nitric oxide synthase is a candidate gene for ADHD and has been previously linked with impulsivity. In the present study, the authors investigated the effect of a functional variable number of tandem repeats (VNTR) polymorphism in NOS1 (NOS1 exon 1f-VNTR) on the processing of rewards, one of the...
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