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Article

Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity.

Molecular psychiatry - 1 Jan 2009

Forbes E E, Brown S M, Kimak M, Ferrell R E, Manuck S B, Hariri A R

Abstract excerpt

Individual differences in traits such as impulsivity involve high reward sensitivity and are associated with risk for substance use disorders. The ventral striatum (VS) has been widely implicated in reward processing, and individual differences in its function are linked to these disorders. Dopamine (DA) plays a critical role in reward processing and is a potent neuromodulator of VS reactivity. Moreover, altered...

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Source

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Identifiers

PMID: 17893706
DOI: 10.1038/sj.mp.4002086
PMCID: PMC2668513

Genes

DRD2
COMT
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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