Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype.

doi:10.1016/j.biopsych.2013.03.027

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Article

Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype.

Biological psychiatry - 15 Oct 2013

Nymberg Charlotte, Jia Tianye, Lubbe Steven, Ruggeri Barbara, Desrivieres Sylvane, Barker Gareth, Büchel Christian, Fauth-Buehler Mira, Cattrell Anna, Conrod Patricia, Flor Herta, Gallinat Juergen, Garavan Hugh, Heinz Andreas, Ittermann Bernd, Lawrence Claire, Mann Karl, Nees Frauke, Salatino-Oliveira Angelica, Paillère Martinot Marie-Laure, Paus Tomas, Rietschel Marcella, Robbins Trevor, Smolka Michael, Banaschewski Tobias, Rubia Katya, Loth Eva, Schumann Gunter

Abstract excerpt

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored. METHODS: Using functional magnetic resonance imaging and genetic analysis of the monoamine oxidase A (MAOA) gene, we investigated how striatal and...

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PMID: 23746540
DOI: 10.1016/j.biopsych.2013.03.027

Genes

MAOA

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