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Article

Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis.

Molecular microbiology - 1 Mar 2001

Johnson C R, Newcombe J, Thorne S, Borde H A, Eales-Reynolds L J, Gorringe A R, Funnell S G, McFadden J J

Abstract excerpt

Two-component regulatory systems are important regulators of virulence genes in a number of bacteria. Genes encoding a two-component regulator system, with homology to the phoP/phoQ system in salmonella, were identified in the meningococcal genome. Allele replacement was used to generate a meningococcal knock-out mutant of the regulator component of this system, and its phenotype was examined. The mutant...

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PMID: 11251849
DOI: 10.1111/j.1365-2958.2001.02324.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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