Article
Oncogene transformation and the metastatic phenotype.
Anticancer research - 1 Jan 2000
Chambers A F, Tuck A B
Abstract excerpt
In this review, we first discuss some of the experimental parameters that need to be considered in assessing the contribution of various oncogenes to tumor metastasis. We discuss the requirement for a number of in vivo assays to measure different aspects of metastatic ability and we describe a novel metastasis assay, which we have developed, in the naturally immune-deficient chick embryo. Other factors capable of...
Topics
- Animals
- Cell Transformation, Neoplastic
- Gene Expression Regulation
- Humans
- Neoplasm Metastasis
- Oncogenes
- Phenotype
- Signal Transduction