Article
Genetically engineered human cancer models utilizing mammalian transgene expression.
Cell cycle (Georgetown, Tex.) - 1 May 2006
Kendall S DiSean, Adam Stacey J, Counter Christopher M
Abstract excerpt
Cancer models are vital to cancer biology research, and multiple cancer models are currently available that utilize either murine or human cells, each with particular strengths and weaknesses. The ability to transform primary human cells into tumors through the expression of specific transgenes offers many advantages as a cancer model, including genetic malleability and the ability to transform specific cell...
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