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Article

Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.

Oncogene - 30 Jul 1998

Lloyd B H, Platt-Higgins A, Rudland P S, Barraclough R

Abstract excerpt

The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the benign rat mammary cell line, Rama 37, yielded cells which expressed a low level of the endogenous...

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Source

Identifiers

PMID: 9696040
DOI: 10.1038/sj.onc.1201948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.PMID 9696040Read ↗

Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka).Semantic proximity Read ↗

Self-association of Calcium-binding Protein S100A4 and MetastasisSemantic proximity Read ↗

Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes.Semantic proximity Read ↗

Production of the metastatic phenotype by DNA transfection in a rat mammary model.Semantic proximity Read ↗

The C-terminal region of S100A4 is important for its metastasis-inducing properties.Semantic proximity Read ↗

S100A4, a mediator of metastasis.Semantic proximity Read ↗

Differential gene expression analysis in a transgenic mouse model of metastatic breast cancerSemantic proximity Read ↗

Expression pattern of S100 calcium-binding proteins in human tumorsSemantic proximity Read ↗

Production of metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA.Semantic proximity Read ↗

Induction of metastatic ability in a stably diploid benign rat mammary epithelial cell line by transfection with DNA from human malignant breast carcinoma cell lines.Semantic proximity Read ↗

The identification of metastasis-related gene products in a rodent mammary tumour modelSemantic proximity Read ↗

Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer.Semantic proximity Read ↗

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