Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.

doi:10.1038/sj.onc.1201948

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Article

Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.

Oncogene - 30 Jul 1998

Lloyd B H, Platt-Higgins A, Rudland P S, Barraclough R

Abstract excerpt

The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 wit...

Topics

Animals
Calcium-Binding Proteins
Carcinogenicity Tests
Cell Line
Female
Humans
Mammary Glands, Animal
Neoplasm Metastasis
Phenotype
RNA, Messenger
Rats
S100 Calcium-Binding Protein A4
S100 Proteins
Transfection

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