Article
The type 2 deiodinase ORFa-Gly3Asp polymorphism (rs12885300) influences the set point of the hypothalamus-pituitary-thyroid axis in patients treated for differentiated thyroid carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Sept 2011
Hoftijzer H C, Heemstra K A, Visser T J, le Cessie S, Peeters R P, Corssmit E P M, Smit J W A
Abstract excerpt
CONTEXT: Iodothyronine deiodinases D1, D2, and D3 play an important role in synthesis and degradation of T(3). The relationship between serum TSH and free T(4) (FT(4)) levels is determined by an individual set point of the hypothalamus-pituitary-thyroid axis. OBJECTIVE: Several polymorphisms have been described in D1 and D2 of which some are associated with serum TSH and iodothyronine levels. In this study we...
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