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Article

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.

British journal of cancer - 12 Jul 2011

Weidlich S, Walsh K, Crowther D, Burczynski M E, Feuerstein G, Carey F A, Steele R J C, Wolf C R, Miele G, Smith G

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor-targeted monoclonal antibody cetuximab (Erbitux) was recently introduced for the treatment of metastatic colorectal cancer. Treatment response is dependent on Kirsten-Ras (K-Ras) mutation status, in which the majority of patients with tumour-specif...

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Identifiers

PMID: 21712828
DOI: 10.1038/bjc.2011.197
PMCID: PMC3142798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21712828-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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