Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

doi:10.18632/oncotarget.5231

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Article

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Oncotarget - 13 Oct 2015

Vincenzi Bruno, Cremolini Chiara, Sartore-Bianchi Andrea, Russo Antonio, Mannavola Francesco, Perrone Giuseppe, Pantano Francesco, Loupakis Fotios, Rossini Daniele, Ongaro Elena, Bonazzina Erica, Dell'Aquila Emanuela, Imperatori Marco, Zoccoli Alice, Bronte Giuseppe, De Maglio Giovanna, Fontanini Gabriella, Natoli Clara, Falcone Alfredo, Santini Daniele, Onetti-Muda Andrea, Siena Salvatore, Tonini Giuseppe, Aprile Giuseppe

Abstract excerpt

INTRODUCTION: Activating mutations of K-Ras gene have a well-established role as predictors of resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (mCRC) patients. Their prognostic value is controversial, and no data regarding the prognostic value of mutation rate, defined as the percentage of mutated alleles/tumor sample, are available. We aimed to evaluate the prognostic value of...

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PMID: 26384309
DOI: 10.18632/oncotarget.5231
PMCID: PMC4741627

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EGFR

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