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Article

Detection of BRAF V600E mutation by pyrosequencing.

Pathology - 1 Apr 2008

Tan Yi Hui, Liu Yanqun, Eu Kong Weng, Ang Pei Woon, Li Wei Qi, Salto-Tellez Manuel, Iacopetta Barry, Soong Richie

Abstract excerpt

INTRODUCTION: Detection of the V600E hotspot mutation in BRAF oncogene is extremely useful for the screening of hereditary non-polyposis colorectal cancer (Lynch's syndrome) and for the prediction of sensitivity to MEK inhibitors. Here we describe a method for detecting this mutation based upon pyrosequencing technology. METHODS: The efficiency of pyrosequencing for detecting BRAF V600E mutations was compared...

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Share to Cell Line, Tumor
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 18428050
DOI: 10.1080/00313020801911512

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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