Article
Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2013
Smith Christopher G, Fisher David, Claes Bart, Maughan Timothy S, Idziaszczyk Shelley, Peuteman Gilian, Harris Rebecca, James Michelle D, Meade Angela, Jasani Bharat, Adams Richard A, Kenny Sarah, Kaplan Richard, Lambrechts Diether, Cheadle Jeremy P
Abstract excerpt
PURPOSE: To study the somatic molecular profile of the EGF receptor (EGFR) pathway in advanced colorectal cancer, its relationship to prognosis, the site of the primary and metastases, and response to cetuximab. EXPERIMENTAL DESIGN: We used Sequenom and Pyrosequencing for high-throughput somatic...
Topics
- Antibodies, Monoclonal, Humanized
- Biomarkers, Tumor
- Carcinogenesis
- Cetuximab
- Class I Phosphatidylinositol 3-Kinases
- Clinical Trials as Topic
- Colorectal Neoplasms
- ErbB Receptors
- High-Throughput Nucleotide Sequencing