Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab.

doi:10.1158/1078-0432.CCR-12-2581

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Article

Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2013

Smith Christopher G, Fisher David, Claes Bart, Maughan Timothy S, Idziaszczyk Shelley, Peuteman Gilian, Harris Rebecca, James Michelle D, Meade Angela, Jasani Bharat, Adams Richard A, Kenny Sarah, Kaplan Richard, Lambrechts Diether, Cheadle Jeremy P

Abstract excerpt

PURPOSE: To study the somatic molecular profile of the EGF receptor (EGFR) pathway in advanced colorectal cancer, its relationship to prognosis, the site of the primary and metastases, and response to cetuximab. EXPERIMENTAL DESIGN: We used Sequenom and Pyrosequencing for high-throughput somatic profiling of the EGFR pathway in 1,976 tumors from patients with advanced colorectal cancer from the COIN trial...

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Identifiers

PMID: 23741067
DOI: 10.1158/1078-0432.CCR-12-2581
PMCID: PMC3732482

Genes

BRAF
KRAS
EGFR
EGF
NRAS

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