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Article

KRAS, BRAF, and TP53 deep sequencing for colorectal carcinoma patient diagnostics.

The Journal of molecular diagnostics : JMD - 1 May 2013

Rechsteiner Markus, von Teichman Adriana, Rüschoff Jan H, Fankhauser Niklaus, Pestalozzi Bernhard, Schraml Peter, Weber Achim, Wild Peter, Zimmermann Dieter, Moch Holger

Abstract excerpt

In colorectal carcinoma, KRAS (alias Ki-ras) and BRAF mutations have emerged as predictors of resistance to anti-epidermal growth factor receptor antibody treatment and worse patient outcome, respectively. In this study, we aimed to establish a high-throughput deep sequencing workflow according to 454 pyrosequencing technology to cope with the increasing demand for sequence information at medical institutions. A...

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Source

Identifiers

PMID: 23531339
DOI: 10.1016/j.jmoldx.2013.02.001

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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