Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.

doi:10.1096/fj.11-189258

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Article

Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2011

Zhou Peng, Fan Lei, Yu Ke-Da, Zhao Ming-Wei, Li Xiao-Xin

Abstract excerpt

The genetic association between a variant in the Toll-like receptor 3 (TLR3) gene (C1234T in mRNA, L412F in protein, Reference SNP Cluster Report rs3775291) and geographic atrophy (GA; also called advanced "dry" age-related macular degeneration) was controversial in previous studies. We performed a meta-analysis by pooling the current evidence in literature and found that the T allele of the TLR3 C1234T variant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21712495
DOI: 10.1096/fj.11-189258

Genes

TLR3

Variants

rs3775291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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