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Article

Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples.

Investigative ophthalmology & visual science - 1 Dec 2009

Cho Youngeun, Wang Jie Jin, Chew Emily Y, Ferris Frederick L, Mitchell Paul, Chan Chi-Chao, Tuo Jingsheng

Abstract excerpt

PURPOSE: Innate immunity appears to play a key role in age-related macular degeneration (AMD). Although two previous studies reported that gene variations in Toll-like receptor (TLR)-3 and -4 are associated with AMD, other studies have not confirmed these associations. In this study, three independent samples (two U.S. clinic-based case-control study samples and one Australian population-based study sample) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19628747
DOI: 10.1167/iovs.09-3688
PMCID: PMC2894575

Genes

TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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