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Article

Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis.

American journal of epidemiology - 15 Jun 2011

Thakkinstian Ammarin, McKay Gareth J, McEvoy Mark, Chakravarthy Usha, Chakrabarti Subhabrata, Silvestri Giuliana, Kaur Inderjeet, Li Xiaoxin, Attia John

Abstract excerpt

The authors performed a meta-analysis to estimate the magnitude of polymorphism effects for the complement component C3 gene (C3) and their possible mode of action on age-related macular degeneration (AMD). The meta-analysis included 16 and 7 studies for rs2230199 and rs1047286, respectively. Data extraction and risk of bias assessments were performed in duplicate, and heterogeneity and publication bias were...

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PMID: 21576320
DOI: 10.1093/aje/kwr025

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