Article
A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population.
PloS one - 1 Jan 2011
Yanagisawa Suiho, Kondo Naoshi, Miki Akiko, Matsumiya Wataru, Kusuhara Sentaro, Tsukahara Yasutomo, Honda Shigeru, Negi Akira
Abstract excerpt
BACKGROUND: Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) in Caucasian populations of European descent. In particular, a nonsynonymous coding variant, rs2230199 (R102G), is presumed to be the most likely causal variant in the C3 locus based on strong statistical evidence for disease association and mechanistic functional...
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