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Article

Toll-like receptor polymorphisms and age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Apr 2008

Edwards Albert O, Chen Dequan, Fridley Brooke L, James Katherine M, Wu Yanhong, Abecasis Goncalo, Swaroop Anand, Othman Mohammad, Branham Kari, Iyengar Sudha K, Sivakumaran Theru A, Klein Ronald, Klein Barbara E K, Tosakulwong Nirubol

Abstract excerpt

PURPOSE: Evidence from genetic-association studies in conjunction with the demonstration of complement deposition in the retina and choroid implicates noncellular pathways of innate immunity in the pathogenesis of age-related macular degeneration (AMD). The purpose of this study was to determine whether common variation in the 10 human toll-like receptors (TLRs) alters the risk of AMD. METHODS: Sixty-eight SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18385087
DOI: 10.1167/iovs.07-1378

Genes

TLR3
TLR4
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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