Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.

doi:10.1167/iovs.07-1575

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Article

Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.

Investigative ophthalmology & visual science - 1 Oct 2008

Shibuya Etsuko, Meguro Akira, Ota Masao, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki, Kawase Kazuhide, Yamamoto Tetsuya, Nakamura Makoto, Negi Akira, Sagara Takeshi, Nishida Teruo, Inatani Masaru, Tanihara Hidenobu, Aihara Makoto, Araie Makoto, Fukuchi Takeo, Abe Haruki, Higashide Tomomi, Sugiyama Kazuhisa, Kanamoto Takashi, Kiuchi Yoshiaki, Iwase Aiko, Ohno Shigeaki, Inoko Hidetoshi, Mizuki Nobuhisa

Abstract excerpt

PURPOSE: Toll-like receptor 4 (TLR4) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands and interacts with heat shock proteins, which are reportedly involved in normal tension glaucoma (NTG). This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG. METHODS: Two hundred fifty Japanese patients with NTG and 318 Japanese healthy control...

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Identifiers

PMID: 18586872
DOI: 10.1167/iovs.07-1575

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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