Article
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.
The New England journal of medicine - 2 Oct 2008
Yang Zhenglin, Stratton Charity, Francis Peter J, Kleinman Mark E, Tan Perciliz L, Gibbs Daniel, Tong Zongzhong, Chen Haoyu, Constantine Ryan, Yang Xian, Chen Yuhong, Zeng Jiexi, Davey Lisa, Ma Xiang, Hau Vincent S, Wang Chi, Harmon Jennifer, Buehler Jeanette, Pearson Erik, Patel Shrena, Kaminoh Yuuki, Watkins Scott, Luo Ling, Zabriskie Norman A, Bernstein Paul S, Cho Wongil, Schwager Andrea, Hinton David R, Klein Michael L, Hamon Sara C, Simmons Emily, Yu Beifeng, Campochiaro Betsy, Sunness Janet S, Campochiaro Peter, Jorde Lynn, Parmigiani Giovanni, Zack Donald J, Katsanis Nicholas, Ambati Jayakrishna, Zhang Kang
Abstract excerpt
BACKGROUND: Age-related macular degeneration is the most common cause of irreversible visual impairment in the developed world. Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown. METHODS: We tested for an association between the functional toll-like receptor 3...
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