Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.

Cellular signalling - 1 Sept 2005

Even-Faitelson Liron, Rosenberg Michael, Ravid Shoshana

Abstract excerpt

Serine/threonine p21-activated kinase is an effector of Rac with a key role in the regulation of cytoskeletal organization. Non-muscle myosin II is a molecular motor, which is an important component of the cytoskeleton. Non-muscle myosin II-B plays a major role in cell motility and chemotaxis. We investigated the role of Rac and p21-activated kinase 1 (PAK1) in the regulation of myosin II-B in prostate cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Cell Shape
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Myosin Light Chains

Share to p21-Activated Kinases

Share to rac GTP-Binding Proteins

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 15993754
DOI: 10.1016/j.cellsig.2004.12.015

Genes

PAK1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.PMID 15993754Read ↗

PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly.Semantic proximity Read ↗

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.Semantic proximity Read ↗

Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and LimitationsSemantic proximity Read ↗

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.Semantic proximity Read ↗

An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex.Semantic proximity Read ↗

p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.Semantic proximity Read ↗

p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.Semantic proximity Read ↗

Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism.Semantic proximity Read ↗

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.Semantic proximity Read ↗

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.Semantic proximity Read ↗

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.Semantic proximity Read ↗

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.