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Article

FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by <i>Pseudomonas aeruginosa</i>

27 Jun 2011

Abstract excerpt

The alveolar epithelium is composed of the flat type I cells comprising 95% of the gas-exchange surface area and cuboidal type II cells comprising the rest. Type II cells are described as facultative progenitor cells based on their ability to proliferate and trans-differentiate into type I cells. In this study, we observed that pneumonia induced by intratracheal instillation of Pseudomonas aeruginosa (PA) in mice...

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PMID: 21708928
DOI: 10.1084/jem.20102041

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