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High Mobility Group Box–1 Mediates Hyperoxia-Induced Impairment of <i>Pseudomonas aeruginosa</i> Clearance and Inflammatory Lung Injury in Mice

1 Mar 2013

Abstract excerpt

Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, a significant number of patients on ventilators exhibit enhanced susceptibility to infections and develop ventilator-associated pneumonia (VAP). Pseudomonas aeruginosa (PA) is one of the most common species of bacteria found in these patients. Previously, we...

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PMID: 23087050
DOI: 10.1165/rcmb.2012-0279oc

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