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Article

Rat alveolar type I cells proliferate, express OCT-4, and exhibit phenotypic plasticity in vitro.

American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2009

Gonzalez Robert F, Allen Lennell, Dobbs Leland G

Abstract excerpt

Alveolar type I (TI) cells are large, squamous cells that cover 95-99% of the internal surface area of the lung. Although TI cells are believed to be terminally differentiated, incapable of either proliferation or phenotypic plasticity, TI cells in vitro both proliferate and express phenotypic markers of other differentiated cell types. Rat TI cells isolated in purities of >99% proliferate in culture, with a...

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Identifiers

PMID: 19717550
DOI: 10.1152/ajplung.90389.2008
PMCID: PMC2793185

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