Article
CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression.
American journal of respiratory cell and molecular biology - 1 Dec 2006
Thompson Charles, Cloutier Alexandre, Bossé Ynuk, Thivierge Maryse, Gouill Christian Le, Larivée Pierre, McDonald Patrick P, Stankova Jana, Rola-Pleszczynski Marek
Abstract excerpt
Because cysteinyl-leukotrienes (cysLTs) are major protagonists in the pathophysiology of human asthma, and because neutrophils are involved in the more severe form of asthma, we studied the potential for leukotriene (LT) D(4) to induce synthesis of the chemokine IL-8 through activation of the CysLT1 receptor. We found LTD(4) to induce IL-8 gene expression in monocytic THP-1 cells and human dendritic cells with...
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