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Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence.

Langenbeck's archives of surgery - 1 Oct 2011

Lee Kyung-Hwa, Lee Ji-Shin, Nam Jong-Hee, Choi Chan, Lee Min-Cheol, Park Chang-Soo, Juhng Sang-Woo, Lee Jae-Hyuk

Abstract excerpt

PURPOSE: Epigenetic silencing of the DNA mismatch repair genes has been poorly described in colorectal carcinomas showing the classic adenoma-carcinoma pathway of carcinogenesis. The aim of this study was to investigate the methylation status of MutL homolog 1 (hMLH1), MutS homolog 2 (hMSH2), and O-6-methylguanine-DNA methyltransferase (MGMT) in a series of colorectal carcinomas that contain both adenomas and...

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PMID: 21706233
DOI: 10.1007/s00423-011-0812-9

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MGMT

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