Article
Clinically important molecular features of Peruvian colorectal tumours: high prevalence of DNA mismatch repair deficiency and low incidence of KRAS mutations.
Pathology - 1 Apr 2011
Egoavil C M, Montenegro P, Soto J L, Casanova L, Sanchez-Lihon J, Castillejo M I, Martinez-Canto A, Perez-Carbonell L, Castillejo A, Guarinos C, Barbera V M, Jover R, Paya A, Alenda C
Abstract excerpt
BACKGROUND: The incidence of colorectal cancer (CRC) in Peru has been increasing, and no data have been published on the molecular features. We explored the most relevant genetic events involved in colorectal carcinogenesis, with clinical implications. METHODS: Using immunohistochemistry for mismatch-repair (MMR) proteins (MLH1, MSH2, MSH6, and PMS2) and microsatellite instability analysis, we evaluated the...
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