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Article

Promoter methylation status ofhMLH1,MGMT, andCDKN2A/p16in colorectal adenomas

1 Jan 2010

Abstract excerpt

AIM: To investigate aberrant DNA methylation of CpG islands and subsequent low- or high-level DNA microsatellite instability (MSI) which is assumed to drive colon carcinogenesis. METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch...

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Share to Colorectal Cancer Screening and Detection
Share to Epigenetics and DNA Methylation
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PMID: 20653064
DOI: 10.3748/wjg.v16.i28.3553

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