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Expression and promoter DNA methylation of MLH1 in colorectal cancer and lung cancer

22 Jan 2017

Abstract excerpt

AIMS: Aberrant DNA methylation is a common molecular feature in human cancer. The aims of this study were to analyze the methylation status of MLH1, one of the DNA mismatch repair (MMR) genes, in human colorectal and lung cancer and to evaluate its clinical relevance. METHODS: The expression of MLH1 was analyzed in 8 colorectal cancer (CRC) and 8 lung cancer cell lines by real-time RT-PCR and western blotting....

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Share to Epigenetics and DNA Methylation
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PMID: 28214209
DOI: 10.1016/j.prp.2017.01.014

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