Article
Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice.
Journal of gastroenterology and hepatology - 1 Oct 2009
Larter Claire Z, Yeh Matthew M, Van Rooyen Derrick M, Teoh Narci C, Brooling John, Hou Jing Yun, Williams Jacqueline, Clyne Matthew, Nolan Christopher J, Farrell Geoffrey C
Abstract excerpt
BACKGROUND AND AIMS: We previously reported that steatohepatitis develops in obese, hypercholesterolemic, diabetic foz/foz mice fed a high-fat (HF) diet for 12 months. We now report earlier onset of steatohepatitis in relation to metabolic abnormalities, and clarify the roles of dietary fat and bodily lipid partitioning on steatosis severity, liver injury and inflammatory recruitment in this novel non-alcoholic...
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