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Article

The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice.

Bone - 1 Oct 2011

Holmes Greg, Bromage Timothy G, Basilico Claudio

Abstract excerpt

We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of proliferative ability with a senescent phenotype. To help understand the role of Sox2 in osteoblast...

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Identifiers

PMID: 21703370
DOI: 10.1016/j.bone.2011.06.008
PMCID: PMC3167013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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