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Article

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.

Molecular and cellular biology - 1 May 2007

Hassan Mohammad Q, Tare Rahul, Lee Suk Hee, Mandeville Matthew, Weiner Brian, Montecino Martin, van Wijnen Andre J, Stein Janet L, Stein Gary S, Lian Jane B

Abstract excerpt

HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 and directly regulates osteoblastic phenotypic genes. In response to bone morphogenic protein BMP2, Hoxa10 is rapidly induced and functions to activate the Runx2...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17325044
DOI: 10.1128/MCB.01544-06
PMCID: PMC1899966

Genes

HOXA10
RUNX2
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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